The Wellcome Trust – HRB Dublin Centre for Clinical Research (DCCR) is a major investment in clinical research infrastructure being made by the Wellcome Trust and HRB. The aim of the DCCR is to provide the infrastructure – the physical space, facilities and trained staff – needed to support collaborative clinical research studies across Dublin involving the TCD, UCD and RCSI Medical Schools, their associated teaching hospitals and Molecular Medicine Ireland. The DCCR network includes research activities taking place at RCSI Clinical Research Centre at Beaumont Hospital and the UCD Clinical Research Centre at Mater Misericordae University Hospital and St. Vincent’s University Hospital and the newly opened Wellcome Trust – HRB Clinical Research Facility at St. James’s Hospital (www.sjhcrf.ie).
The Objectives of the Dublin Centre for Clinical Research
The specific objectives of the Dublin Centre for Clinical Research (DCCR) are:
- Construction and operation of the Wellcome Trust - HRB Clinical Research Facility (CRF) at St. James’s Hospital;
- Development of a programme of advanced therapeutics within the St James’s Hospital CRC; and
- Delivery of clinical research programmes, primarily in cancer, neuro-psychiatric disease, and infection and immunity, supported by a citywide network.
The development of the city-wide clinical research network involves the development of a shared clinical research informatics network and the training and education programmes for research nurses.
DCCR Organisation and Structure
The DCCR is a clinical research collaboration between TCD, UCD, RCSI, MMI and the associated Dublin Area teaching hospitals. Because of its large population Dublin is the focus of the DCCR’s clinical research activities. However, in some areas studies are supported by DCCR Network infrastructure across the country.
DCCR Governance Arrangements
As TCD is the host institution for this award, it has ultimate responsibility to the Wellcome Trust and Health Research Board. TCD is supported in this role by the DCCR Consortium Board, which is comprised of representatives from the DCCR partner organisations (TCD, RCSI, UCD, MMI and St. James’s Hospital).
In addition, the HRB, Wellcome Trust and TCD have agreed to establish a DCCR Oversight Board to independently report on the progress of the DCCR Programme. The Oversight Board is comprised of an internationally recognised panel with expertise in the area of clinical research facilities, networks and programmes.
The DCCR Programme is operationally managed as two interrelated sub-programmes. At the St. James’s Hospital campus, the Clinical Research Facility is jointly governed by St. James’s Hospital Board and TCD through a Governance Board.
Secondly the DCCR Network Management Team manages the development of city-wide infrastructure for clinical research and the implementation of city-wide multisite clinical research activities. The research programmes supported by the network are driven by DCCR Clinical Interest Groups, where clinicians and scientists from across the city have come together around particular clinical research themes. The Network Management Team is supported by the DCCR Network Operations Team, which is responsible for establishing standard network operating procedures for multi-site clinical research (DCCR Clinical Research Portfolio), network training and education (e.g. Certificate Course in Research Nursing and ICRIN GCP) initiatives as well as the development of clinical research IT infrastructure.