Course Information
MMI Course: POPULATION GENETICS & SNP ANALYSIS
Date(s): 10 June 2008
Online Application Period: 12 May - 9 Jun 2008
Venues: Cheyne Lecture Theatre, Royal College of Surgeons in Ireland, Dublin
Download the course poster here
| IMPORTANT: This course comprises a lecture element (Day 1) and a practical workshop (Day 2). Please note that there is a limited number of places available for the practical workshop. You must first apply online here. If you only wish to attend the lecture element of the course (Day 1), this is all what you need to do at this stage. If you also wish to attend the practical workshop (Day 2), then after applying online, please send an Email to education@MolecularMedicineIreland.ie expressing your interest. Please note that those attending the practical workshop must also attend the lecture element of the course. |
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The analysis of genetic determinants in human disease, particularly in multifactorial conditions such as cardiovascular disease, has advanced markedly in recent years due to the availability of high-density maps of Single Nucleotide Polymorphism (SNP) markers, new insights into human genome structure from the International HapMap Project and novel analytical methods. This course, running over two days, aims to introduce researchers to key strategic considerations in designing and performing gene-mapping studies using SNP markers. It will also provide ‘hands-on’ experience of data analysis.
Day 1 (10 June) will focus on the nature and dynamics of SNP markers in populations, associations between markers due to the haplotype ‘block’ structure of the human genome and public domain resources for gene-mapping studies. Talks on applying these tools to clinical problems and the evolution of populations includes two Plenary Lectures on Epilepsy genomics (Dr Sanjay Sisodiya, University College London Hospital) and Population genomics of human gene [removed]Dr Emmanouil T. Dermitzakis, Wellcome Trust Sanger Institute).
Day 2 (11 June) is designed as a ‘hands-on’ practical workshop that examines resources for selecting SNPs, issues around study design & power and data management, and will give time for some basic analyses of SNP data. Please see here for more information on Day 2.
LECTURE SESSION: Tue 10 June (1000-1800)
| 1000 | Introduction to SNP's Prof David Croke (RCSI) |
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| 1020 | Introduction to and history of gene-disease association studies Prof Denis Shields (UCD) |
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| 1040 | Overview of database resources Dr Ross McManus (TCD) |
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| 1100 | Introduction to study design Prof Denis Shields (UCD) |
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| 1120 | Coffee/Tea break | |
| 1140 | Overview of software resources Dr Anthony Ryan (TCD) |
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| 1205 | Developments in Biobanking Dr Joe McPartlin (TCD) Abstract |
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| 1220 | Next Generation Sequencing Technologies Dr Derek Morris (TCD) |
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| 1235 | High-throughput genotyping platforms & technology Dr Sean Ennis (UCD) |
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| 1250 | Lunch provided | |
| 1340 | Keynote lecture: Epilepsy genomics Prof Sanjay Sisodiya (University College London Hospital) |
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| 1430 | Coeliac genetics: Recent insights from genome wide studies Dr Ross McManus (TCD) |
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| 1500 | Identigen Dr Ronan Loftus (TCD) |
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| 1530 | Coffee/Tea break | |
| 1600 | Optimising study design for whole genome association Dr Gianpiero Cavalleri (RCSI) |
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| 1630 | Signatures of Selection Prof Dan Bradley (TCD) |
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| 1700 | Keynote lecture: Population genomics of human gene expression Dr Emmanouil T. Dermitzakis (Wellcome Trust Sanger Institute) |
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| 1800 | Wine Reception - Sponsored by Affymetrix | |
Course Coordinators
Prof David Croke (Molecular & Cellular Therapeutics, RCSI)
Dr Ross McManus (Institute of Molecular Medicine, St James's Hospital, TCD)
Prof Denis Shields (UCD Conway Institute of Biomolecular & Biomedical Research)
Course Speakers
Prof Dan Bradley (Smurfit Institute of Genetics, TCD)
Dr Gianpiero Cavalleri (Department of Neurology, RCSI)
Dr Emmanouil T. Dermitzakis (Wellcome Trust Sanger Institute, Hinxton, UK)
Dr Sean Ennis (Our Lady's Hospital for Sick Children and School of Medicine & Medical Science, UCD)
Dr Joe McPartlin (Institute of Molecular Medicine, St James's Hospital, TCD)
Dr Derek Morris (Institute of Molecular Medicine, St James's Hospital, TCD)
Prof Sanjay Sisodiya (University College London Hospital)
Dr Anthony Ryan (Institute of Molecular Medicine, TCD)
Course Sponsors
Basic Sponsor
Affymetrix is sponsoring
the wine reception on Tuesday
