Download the course poster here 
 

The analysis of genetic determinants in human disease, particularly in multifactorial conditions such as cardiovascular disease, has advanced markedly in recent years due to the availability of high-density maps of Single Nucleotide Polymorphism (SNP) markers, new insights into human genome structure from the International HapMap Project and novel analytical methods. This course, running over two days, aims to introduce researchers to key strategic considerations in designing and performing gene-mapping studies using SNP markers. It will also provide ‘hands-on’ experience of data analysis.

Day 1 (10 June) will focus on the nature and dynamics of SNP markers in populations, associations between markers due to the haplotype ‘block’ structure of the human genome and public domain resources for gene-mapping studies. Talks on applying these tools to clinical problems and the evolution of populations includes two Plenary Lectures on Epilepsy genomics (Dr Sanjay Sisodiya, University College London Hospital) and Population genomics of human gene (Dr Emmanouil T. Dermitzakis, Wellcome Trust Sanger Institute). Please see here for more information on Day 1

Day 2 (11 June) is designed as a ‘hands-on’ practical workshop that examines resources for selecting SNPs, issues around study design & power and data management, and will give time for some basic analyses of SNP data.