MMI Course: Drug Design & Delivery

Title: MMI Course: Drug Design & Delivery

Date(s): 12-13 October 2009

Main Venue:
Royal College of Surgeons in Ireland
123 St Stephens Green, Dublin 2

Location »

Online Application Period: 6 Sep - 7 Oct 2009

Download the course poster here
Course Programme to print here

Please find a report of the course here

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Programme

Faculty

Sponsor

This course is designed to give clinicians and researchers from the life, chemical and physical sciences a broad overview of the concepts, strategies and research techniques used in drug design and delivery. Basic understanding of molecular structures would be an advantage but is not required and you should not need prior knowledge of the models and techniques covered in the course.

The objective for postgraduate teaching is to give students an overview and illustration of how the interaction of a drug target (generally a protein) with a small molecule or a macromolecule can be optimised (in silico or in vitro) to develop a pharmaceutical or bio-pharmaceutical agent. Besides the optimisation of the affinity and selectivity of these drug candidates for the therapeutic target, other key issues to be considered at the drug discovery & development stages, such as absorption, distribution, metabolism and excretion (ADME) properties, protection of the intellectual property and regulatory affairs will also be introduced.

Many promising and highly active new drugs never go beyond the laboratory because of problems associated with their formulation and delivery. A series of drug delivery lectures will highlight the impact of drug structure and design on a molecule’s pharmaceutical and biopharmaceutical properties and ultimately on its’ pharmaceutical development into a final product. Specific lectures will cover the challenges associated with the delivery of macromolecules.

 Day 1: Mon 12 Oct; 0900-1720 

0900	Keynote: Chemistry and Pharmaceutical Industry, the new perspectives Professor Bertrand Castro (Sanofi-Aventis)
0940	Molecular basis of drug action: drug receptor interactions Dr Isabel Rozas (TCD)
1020	Molecular basis of drug action: catalytic receptors, enzymes and their inhibition Dr Ciaran Carolan (European Molecular Biology Laboratory Hamburg)
1100	Coffee/Tea
1130	Natural products as leads in drug design Dr James Barlow (RCSI)
1210	The concept of pharmacophore: informatics perspective Prof Denis Shields (UCD)
1250	Lunch
1330	The concept of pharmacophore: biological perspective Prof Niamh Moran (RCSI)
1410	Rational drug design: structure/activity relationships Dr Isabel Rozas (TCD)
1450	Coffee/Tea
1520	Rational computer-aided drug design Dr Darren Fayne (TCD)
1600	Techniques in rational drug design: X-ray crystallography & NMR Dr Amir Khan (TCD)
1640	*Gene Delivery: from molecular packaging to targeting Prof Caitriona O’Driscoll (UCC)
	Click here for abstracts and recommended reading

Day 2: Tue 13 Oct; 0900-1720

0900	*The role of drug delivery in drug design and development Dr Sally-Ann Cryan (RCSI)
0940	*Oral delivery of macromolecules: challenges and opportunities  Prof David Brayden (UCD)
1020	*Patient Oriented Drug Delivery Dr John Fox (Merrion Pharmaceuticals) Ms Bozena Adamczyk (Merrion Pharmaceuticals)
	*The above lectures are provided by investigators and industry collaborators in the Irish Drug Delivery Network
1100	Coffee/Tea
1130	Lead optimisation: from active molecule to clinical candidate Prof Mary Meegan (TCD)
1210	The clinical trials process Ms Siobhan Gaynor (Irish Clinical Research Infrastructure Network)
1250	Lunch
1330	Case studies in drug design and development Prof Mary Meegan (TCD)
1400	The impact of regulatory affairs in drug discovery Dr Chantal Le Floch (Servier Research Group)
1440	Drug development: The industry perspective Dr Damian O'Connell (Pfizer)
1510	Coffee/Tea
1540	IP issues in drug development Dr Richie Paul (Elan)
1610	Commercialisation Mr Colin Sainsbury (BCM Hanby Wallace)
1640	Concluding remarks  Dr Marc Devocelle (RCSI)
	Click here for abstracts and recommended reading

Course Faculty
Course Coordinator:
Dr Marc Devocelle (Department of Pharmaceutical Chemistry, RCSI)

Ms Bozena Adamczyk (Formulation Scientist, Merrion Pharmaceuticals)
Dr James Barlow (School of Pharmacy, RCSI)
Prof David Brayden (UCD School of Agriculture, Food Science, & Veterinary Medicine and UCD Conway Institute)
Professor Bertrand Castro (Scientific Director Industrial Affairs, Sanofi-Aventis)
Dr Sally-Ann Cryan (School of Pharmacy, RCSI)
Dr Darren Fayne (Molecular Design Group, School of Biochemistry and Immunology, TCD)
Dr John Fox (Chief Development Officer, Merrion Pharmaceuticals)
Dr Amir Khan (School of Biochemistry and Immunology, TCD)
Dr Chantal Le Floch (Servier Research Group)
Prof Mary Meegan (School of Pharmacy & Pharmaceutical Sciences, TCD)
Prof Niamh Moran (Department of Clinical Pharmacology, RCSI)
Dr Damian O'Connell (Executive Director and Pain Therapeutic Area Development Team Leader, Pfizer)
Prof Caitriona O’Driscoll (School of Pharmacy, UCC)
Dr Richie Paul (Head of IP, Elan Drug Technologies)
Dr Isabel Rozas (School of Chemistry, TCD)
Colin Sainsbury (Partner, BCM Hanby Wallace)
Prof Denis Shields (UCD Conway Institute of Biomolecular & Biomedical Research)

Course Sponsor