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Contents
In this issue:
- Welcome to Issue 3 - October 2009
- First MMI Clinician Scientist Fellowship Programme Annual Meeting held at NUI Galway
- MMI course - Techniques & Strategies in Molecular Medicine: Online application invited
- Marie Mellody appointed as ICRIN Coordinator
- MMI Guidelines for Standardised Biobanking
- Industry and academia come together to deliver MMI Drug Design & Delivery course
- RCSI Certificate Course in Research Nursing Launched in Newman House
- MMI and CAMI workshop highlights applications of MRI in research
- MMI mapping Research Technology Platforms
- MMI / HRB CRF Galway Workshop in Biostatistics
- UK CRF Network Road Show Comes to Ireland
- Minister Lenihan Opens Irelands First Next-Generation DNA Sequencing Laboratory at TCDs Institute of Molecular Medicine
- News In Brief
- Upcoming Events
Welcome to Issue 3 - October 2009
Measuring the value of medical research
The Report of the Expenditure Review Group (McCarthy Report), established by Government to advise on reductions in public expenditure in response to the collapse in the tax base, raised fundamental questions about the economic return of investment in research. The Report recommended that, in future, decisions to invest public funds in research should be made only on the basis of a demonstrable return to the economy within 3-5 years. This focus on ‘applied’ research, in which it may be possible to calculate a short term economic benefit, as distinct from investment in fundamental research, where the returns may not be apparent for a longer period, was challenged by Professor Luke O’Neill in an excellent newspaper article.i The case for continued investment in fundamental research was well argued by Professor Patrick Cunningham, the Chief Scientific Advisor, in an article he wrote on the role sustained investment will play in wider recovery strategy.ii It was encouraging that many representatives of the Irish diaspora at the economic summit in FarmLeigh House in September urged the Government to continue its policy of investment in science and research as a strategy for emerging from the recession in good shape.
While few would argue with the statement that today’s health research is tomorrow’s health care, can we marshal hard evidence of the return of investment in medical research? In 2008, the Health Research Board published an important contribution to the literature of evaluating the impact of investment in health research.iii Using the ‘payback’ method, the HRB, Rand Europe and the Health Economics Research Group at Brunel University, estimated the economic impact, the influence on government policy and improvements to people’s lives of research investments made by the HRB in the early and mid-1990s. They found, for example, that research on the role of eicosanoids in pain produced a range of impacts including an improved and more cost effective dosing regime for patients with arthritis and produced three spin-off companies.
Last year, the Wellcome Trust, the Medical Research Council and the Academy of Medical Sciences published a study of the economic benefits from medical research in the UK.iv Undertaken by Brunel University and Rand Europe, the research identifies the key economic benefits of medical research as 1) health gains – net of the costs to the health services of delivering them – and 2) the gains to GDP that result directly and indirectly from medical research. They found that a £1 investment of public or charitable funds in cardiovascular disease research yielded a stream of benefits to the UK thereafter equivalent in value to earning £0.39 per year in perpetuity. The equivalent rate of return for investment in mental health research was £0.37 for every £1 invested. A good return on investment by any standard! One message from the research is that the impact of investment in medical research takes time to emerge - in cardiovascular disease, for example, the lag between investment and impact is between 10 and 25 years.
Fortunately, there is also evidence that Government appreciates the economic benefits of medical research. In the Programme for Government recently agreed by the parties in Government, the benefits to the economy of increased research and development in the health sector are explicitly recognised. MMI welcomes the commitment in the Programme to 'making Ireland a leading country for timing, access and relevance of clinical trials' v and to building on existing research projects. The expected publication of the Health Research Action Plan by the Departments of Health and Children and Enterprise, Trade and Employment will be an important step in maximising health gain and economic return from existing and planned investments in medical research.
Ruth Barrington PhD
i http://www.irishtimes.com/newspaper/opinion/2009/0818/1224252768970.html
ii http://www.irishtimes.com/newspaper/sciencetoday/2009/0827/1224253326151.html
iii http://www.hrb.ie/research-strategy-funding/publications/rsf-publication/publications//309
iv Medical Research Council, the Wellcome Trust and the Academy of Medical Sciences ‘Medical Research: What’s it worth? Estimating the economic benefits from medical research in the UK’, November 2008. http://www.wellcome.ac.uk/About-us/Publications/Reports/Biomedical-science/WTX052113.htm
v http://www.scribd.com/doc/20877317/Renewed-Programme-for-Government-10-10-09 p 17
First MMI Clinician Scientist Fellowship Programme Annual Meeting held at NUI Galway
The first MMI Clinician Scientist Fellowship Programme (CSFP) Annual Meeting took place on Saturday 11 July 2009 at NUI Galway.
The objective of the CSFP is to train the next generation of clinician scientists with the unique and specialised knowledge essential to fulfil Ireland’s research needs in translational medicine. The CSFP is funded by the Irish Government under the Programme for Research in Third Level Institutions Cycle 4. Fellows from five institutions with a shared agenda in clinical and translational research are participating in the Programme, which is being coordinated by Molecular Medicine Ireland. 22 MMI Fellows have been appointed to date.
The CSFP Annual Meeting gathered key individuals involved in this MMI programme, including the Fellows’ supervisors. Professor Terry Smith, Vice-President for Research at NUI Galway, welcomed the delegates to the meeting. 19 MMI Fellows appointed in the first call for the programme presented their research as short talks and posters were presented by 3 Fellows appointed in the second call for the programme.
A highlight of the day was the Keynote Lecture delivered by Professor Sherine Gabriel (William J. and Charles H. Mayo Professor of Medicine and Epidemiology, Mayo Clinic, MN, US), the title of which was ‘Heart Disease and Premature Death in Rheumatoid Arthritis: Lessons from Epidemiology’.
Prof Gabriel (on the left) & Dr Christine Dingivan (PPD, Inc) during the meeting
A judging panel, comprising Prof Matthew Griffin (Professor of Transplant Biology at NUI Galway), Dr Christine Dingivan (Executive Vice President and Chief Medical
Officer, PPD) and Prof Gabriel awarded the MMI medal (on the right) for best presentation to Dr Aoife Lowery (NUI Galway) for her presentation on ‘Breast Cancer associated microRNAs – classification using expression profiling and artificial neural networks’. Second and third prizes were awarded to Dr Fionnuala Ni Ainle (TCD) and Dr Oliver Schubert (RCSI), respectively.
‘Today is a milestone in the Clinician Scientist Fellowship programme’ commented Dr Ruth Barrington, CEO of MMI. ‘The research presented by the Fellows is at the cutting edge of science and is of great significance for more effective diagnosis of disease and treatment of patients. The Fellows are contributing to Ireland’s reputation for excellence in clinical and translational research. They are also making Ireland a more attractive place for investment by healthcare industries in research and development’, she said.
The Annual Meeting was preceded by a week of Structured Training at NUI Galway, which brought the MMI Fellows together for education modules covering research and translational skills. This was the third period of Structured Training for the Fellows and it included modules on Biostatistics, Biomaterials/Bioengineering, Paper review, Grant writing, Bibliometrics, Intellectual Property and Patents, Advanced Imaging, and a series of Techniques workshops.
MMI course - Techniques & Strategies in Molecular Medicine: Online application invited
Title: Techniques & Strategies in Molecular Medicine
Date: 8-9 December 2009 (two full days)
Venue: UCD Conway Institute of Biomolecular & Biomedical Research, Dublin4
Online Application Period: 9-27 November 2009
This MMI course, running over 2 full days, is designed to give bioscientists and clinicians a broad overview of research techniques and their application. Basic molecular biology laboratory experience is assumed, but you should not need prior knowledge of the techniques covered in the course.
See here for further details.
Marie Mellody appointed as ICRIN Coordinator
Molecular Medicine Ireland is pleased to announce the appointment of Marie Mellody as Coordinator of the Irish Clinical Research Infrastructure Network (ICRIN) with responsibility for leading the development of ICRIN as a national coordinating centre for clinical research in Ireland and representing Ireland in the European Clinical Research Infrastructure Network.
Marie comes to the post with a formidable track record in the conduct and coordination of clinical research comprising over 20 years experience in all phases of clinical development in the pharmaceutical, biotechnology and contract research industry.
A science graduate of NUI Galway, Marie has held operations management positions in Hoechst Marion Roussel, Abbott and Serono International S.A. and has service provider experience at the Institute of Clinical Pharmacology, ClinTrials and ICON. Since 2004, Marie has developed an innovative, pan European clinical research network with the objective of identifying a more streamlined and fit for purpose approach to clinical operation and clinical trials. For the past three years, she has provided consultancy services to in the UK non-commercial and academic sector to improve the organisation of their clinical studies and to coordinate regulatory compliance.
Dr Ruth Barrington CEO of MMI said how pleased she was that Marie had taken up the post at this time. “The benefits of a national infrastructure for clinical research, linking existing and planned facilities, tapping into the expertise in all facilities and promoting a harmonised approach to clinical studies are becoming apparent to more and more people. Marie will bring her extensive experience of organising clinical research to the task of developing ICRIN - for the benefit of patients, to enhance the research capacity of our academic institutions and to support the Government’s innovation agenda in the life sciences. “
Marie Mellody took up her post on 17 August 2009. She can be contacted at: Marie.Mellody@MolecularMedicineIreland.ie
MMI Guidelines for Standardised Biobanking
MMI in association with its partners has recognised the need to develop guidelines to standardise the collection, processing and storage of biological materials across the different clinial and research centres in Ireland. The use of standardised protocols for sample collection, processing and storage will help to provide the proper safeguards and assurances required for sample quality, consistency and integrity among bio-collections at different sites. This harmonisation should allow for the universal interchange of biological materials across sites and the amalgamation of samples for research studies. In addition standardisation of bio-collections will ensure that molecular changes identified by subsequent research studies will reflect biology and not process and for sample variability.
These guidelines will be drafted with reference to national and international best practice guidelines. It is hoped that the adoption of these guidelines will help to provide a structured framework to standardise current biobanking activities.
Industry and academia come together to deliver MMI Drug Design & Delivery course
The fourth running of the MMI Drug Design & Delivery course took place on 12-13 October 2009 in RCSI. An audience of 59 postgraduate students and postdoctoral researchers heard 21 lectures over the two days. Participants came from the five MMI partner institutions and from Queen’s University Belfast, DIT, DCU and Opsona Therapeutics.
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| The course began with a keynote lecture from Prof. Bertrand Castro (Sanofi-Aventis) |
The course opened with a thought-provoking keynote lecture from Professor Bertrand Castro (Scientific Director Industrial Affairs, Sanofi-Aventis). Professor Castro discussed the challenges faced by the pharmaceutical industry today. With the era of the ‘blockbuster’ drug believed to be over, possible new directions include multitherapy (e.g. the ‘polypill’), and drug repositioning (existing drugs for new indications).
The first day’s lectures covered aspects of drug design including drug-receptor interactions, the potential for enzyme inhibitors, natural products as leads in drug design, and structure-activity relationships. In the afternoon session, the focus was on rational computer-aided drug design and the techniques for determining molecular structure.
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| Dr Richie Paul (Elan) gave a lecture on intellectual property |
The second day included lectures on drug delivery by researchers from the SFI-funded Irish Drug Delivery Network and their industrial collaborators in Merrion Pharmaceuticals. An insight into the clinical trials process was given by the Irish Clinical Research Infrastructure Network (ICRIN). An industry perspective on drug development was given by Dr Damian O’Connell (Executive Director, Pfizer and Chair of the MMI Board) and Dr Chantal Le Floch (Servier) gave an insight into regulatory affairs.
The course concluded with lectures on the management of intellectual property and the processes involved in the commercialisation of discoveries in the life sciences sector.
Attendees of the course will also have the opportunity to visit the TCD 3D visualisation facility, which enables researchers to view the interactions between receptors and candidate drugs.
For full details of the course schedule and faculty please see the course page at:
http://www.molecularmedicineireland.ie/education/course_info/1/151/1
RCSI Certificate Course in Research Nursing Launched in Newman House
A reception was hosted in Newman House on St Stephen's Green, Dublin for the pioneering cohort of Research Nurses registering for the country's first course dedicated to research nursing. Twelve nurses from Dublin, Cork and Galway, the course faculty and student mentors attended a reception hosted by Molecular Medicine Ireland on 8th September. Ruth Barrington, CEO of Molecular Medicine Ireland, highlighted the importance of the occasion: "This provides a critical part of the infrastructure we are building to support collaborative clinical research across Ireland", she reported as she welcomed the guests to the event and praised the persistence of the RCSI who had the foresight to see a need for training nurses specialising in research nursing.
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| From left to right: Dr Ruth Barrington (CEO, MMI), Dr Mark Watson (Education & Training Manager, MMI), Professor Seamus Cowman, (Professor of Nursing, RCSI), Professor Dermot Kenny, Clinical Director of the RCSI’s CRC) |
“In clinical research, research nurses play an important role in looking out for the interests of patients and their families and much of this course is about learning to play this role in a clinical research setting.” said Professor Seamus Cowman, RCSI’s Professor of Nursing. The course is a Level 9 course with full NUI accreditation. The hope is that students will go on to supplement this course with further related master’s level courses and use it as a stepping stone to achieving a range of postgraduate qualifications in health sciences. Professor Dermot Kenny, Clinical Director of the RCSI’s Clinical Research Centre and Associate Director of the Dublin Centre for Clinical Research, emphasised the importance of research nursing to the clinical research endeavour. “Without you, clinical research doesn’t happen”. The course was developed as part of the Dublin Centre for Clinical Research, a programme of clinical research jointly funded by the Health Research Board and the Wellcome Trust. Jeremy Towns, Programme Manager for the DCCR welcomed the opportunity the course provides for research nurses to network and get to know each other, as from now on, there will be a growing number of collaborative multi-site studies being carried out in Dublin and across Ireland.
MMI and CAMI workshop highlights applications of MRI in research
Molecular Medicine Ireland linked with the HRB-funded Centre for Advanced Imaging (CAMI) at St James’s Hospital, Dublin to deliver a half-day workshop that highlighted the opportunities and advantages of using Magnetic Resonance Imaging (MRI) in clinical and translational research. Applications include tumour imaging, investigation of cardiovascular function and imaging of neural activity. MRI techniques can progress research from animal models through to human clinical application, and the absence of ionising radiation faciltates serial/repeat imaging in patients and the study of healthy volunteers.
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| Dr Martin Graves (University of Cambridge) presents his keynote lecture during the workshop |
The workshop, which was held on 17 September 2009, assembled seven speakers with a vast experience of applying MRI as a research tool. Dr Mark Watson (MMI Manager of Education & Training) introduced the proceedings, highlighting that CAMI links with MMI are not only in the education and training sphere but also focus on promoting the CAMI technology platform as a national resource. The workshop began with an introduction to CAMI from Director Dr Jim Meaney and ended with guidance on how to access the technology and plan an MRI project from CAMI Physicist Dr Andrew Fagan. In between was a wide-ranging look at how MRI is currently used in research and state-of-the-art diagnostics and the very exciting future applications that will see MR imaging at the molecular level.
Dr Gerard Boyle (Principal Physicist, SJH) described the components and principles of an MRI system with the aid of an excellent graphical presentation. This set the scene for the keynote lecture from Dr Martin Graves, Head of the MR Physics and Informatics Group at Cambridge University Hospitals NHS Foundation Trust. After consideration of the pros and cons of the technology, Dr Graves took the audience on a tour of various techniques and capibilities of MRI in the research setting. This included the use of Diffusion Weighted Imaging and Dynamic Contrast Enhanced Imaging to visualise cell swelling following stroke and tumour response to chemotherapy, MR Elastography as a non-invasive method to quantify tissue stiffness in liver fibrosis, and use of multi-contrast MRI for biomechanical modelling to study carotid plaque rupture in stroke. Dr Graves concluded with an insight into the latest developments in molecular imaging including MRI mapping of enzyme activity in real time.
The workshop continued with Dr Andrew Fagan providing an overview of animal imaging in MRI, followed by Dr Jim Meaney with a presentation of MRI research tools in human disease. Prof Yurii Gun’ko (TCD) described the development of new magnetic nanoparticle fluids as contrast agents; these have shown good biocompatibility and potential for MRI. Dr Caroline Daly (St James’s Hospital) focused on the use of MRI in cardiovascular disease research and Prof Thomas Frodl (TCD) described its use in the neuroimaging of psychiatric diseases, where current research is on detection of the biological basis of mood disorders and schizophrenia and discovery of biomarkers for treatment response.
This very successful workshop presented current applications of MRI in research, indentified where the technology is heading, and broadcast the availability of a national MRI platform dedicated to research at the Centre for Advanced Imaging. Guest keynote speaker, Dr Martin Graves, commented “Recent developments in hardware, software and contrast agents has allowed magnetic resonance imaging to not only produce exquisite images of organ morphology and function but also to provide some unique capabilities to image cellular and molecular processes”.
For more information on the workshop, including abstracts, see: http://www.molecularmedicineireland.ie/education/course_info/1/145/1
For more information on CAMI see: http://www.3tcentre.com/
MMI mapping Research Technology Platforms
MMI is in the process of mapping the technology platforms and associated expertise available across our partner institutions and proposes to develop a portal on the MMI website which will provide a central location to promote and showcase these technology platforms.
If you would like your technology platform included in MMI's mapping exercise please contact Jan Guerin, Programme Manager Research at jan.guerin@molecularmedicineireland.ie
MMI / HRB CRF Galway Workshop in Biostatistics
An MMI / HRB CRF Galway Workshop in Biostatistics was held from 6-10 July 2009 in Aras Ui Chathaill, NUI Galway. The workshop was held as part of the MMI CSFP Structured Training and was opened up to a wider audience of researchers from the CRF as well as from other MMI partner institutions and industry. Running over five mornings, the workshop was limited to 56 attendees and attracted significant interest.
The aim of the workshop, which was run by Dr John Newell (Dept of Mathematics and
HRB CRF, NUI Galway) together with Professor Tom Aitchison (formerly Department of Statistics, University of Glasgow, Scotland, UK) was to provide participants with an overview of fundamental biostatistical methods, an understanding of the key concept of variability and a practical working knowledge of the statistical techniques they are likely to encounter in applied medical research.
Techniques covered included study design, analysis of sample problems (independent 
and dependent data) through interval estimation and hypothesis testing approaches, comparison of three or more samples (analysis of variance), regression problems, survival analysis, logistic regression and sample size calculations. Each session was designed in the format of a workshop and included lectures and computer based practical work.
Participants on the Biostatistics workshops were also eligible to attend additional l
ectures and workshops taking place each afternoon as part of the MMI CSFP Structured Training. Topics covered included Biostatistics, Biomaterials/Bioengineering, Paper review, Grant writing, Bibliometrics, Intellectual Property and Patents, Advanced Imaging, and a series of Techniques workshops (e.g. FACs, Real-time PCR, Microarray, Immunohistochemistry). They were also keynote presentations from Prof Matthew Griffin (NUI Galway) and Dr Christine Dingivan (of the clinical research organiation PPD, inc: pictured right)
For more information on the MMI CSFP please see here
UK CRF Network Road Show Comes to Ireland
The Dublin Centre for Clinical Research (DCCR) and the Royal College of Surgeons in Ireland CRC at Beaumont Hospital hosted a Road Show on 23rd June, exhibiting the UK Clinical Research Facilities Network Information Portal. Over 30 researchers from Ireland and Northern Ireland attended the event which featured presenters from both parts of Ireland and also from England.
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| (From left) Jeremy Towns, DCCR; Shane Hoy, UK Clinical Research Facilities Network; Michael Neely, Northern Ireland HSC R&D Office |
In the afternoon, Shane Hoy of the UK Clinical Research Infrastructure Network presented the information portal, which is used to share information and an array of documentation on use to clinical research facilities. Already, about 10% of the portals registered users are based in Ireland. Mr Hoy illustrated how easy the portal is to use and how the value of information developed in other locations can be amplified by its reuse and adaptation. Mary McGrath of the UCD CRC also introduced the group to the Irish Research Nurses Network and explored ideas of how this group could work on an all-Ireland basis. Deirdre Hyland of the RSCI gave a talk on the new Research Nursing Certificate Course and Charlene Grice of ICRIN spoke about the Good Clinical Practice (GCP) course being organised across the Dublin area CRCs.
Minister Lenihan Opens Irelands First Next-Generation DNA Sequencing Laboratory at TCDs Institute of Molecular Medicine
Minister for Science, Technology & Innovation, Conor Lenihan T.D. recently opened Ireland’s first Genome Sequencing Laboratory, a new cutting-edge DNA sequencing laboratory enabling research into psychiatric disorders, cancers, infectious diseases and conditions affecting the immune system, based in Trinity College Dublin’s Institute of Molecular Medicine.
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| (From left) Prof. Michael Gill, TCD; Dr Stephen Simpson, SFI; Mr. Conor Lenihan, T.D.; Dr. Derek Morris, TCD, Prof. Dermot Kelleher, TCD |
Science Foundation Ireland (SFI), funded the new Trinity Genome Sequencing Laboratory as a national platform which houses an ‘Illumina Genome Analyzer II’, the first ‘next generation DNA sequencing’ platform to be set up in Ireland. This national platform allows scientists to undertake studies in molecular biology and genetics research that were previously not technically or economically feasible. This ultra-high throughput sequencing technology therefore facilitates a range of genetics studies that were previously not possible and has already started to revolutionize genetics research world-wide. The range of genetics applications available include (i) DNA Sequencing, (ii) Transcriptome Analysis and (iii) Studies of Gene Regulation and Control. The successful award from SFI involved investigators from Trinity College Dublin, Royal College of Surgeons in Ireland, University of Dublin and National University of Ireland Galway.
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Image above: Mr. Conor Lenihan, T.D., Minister for Science, Technology & Innovation and Dr. Elaine Kenny, Trinity Genome Sequencing Laboratory |
The Trinity Genome Sequencing Laboratory as a national platform is supported by full time research staff available to all academic and industry based researchers in Ireland. This facility provides assistance to researchers interested in undertaking a project using the Illumina Genome Analyzer in the following key areas:
- Advice on study design and costs
- Advice and guidance on sample preparation
- Library preparation, cluster generation, sequencing and primary data analysis
- Advice and guidance on secondary data analysis
For project enquiries/project quotes please contact: Dr Derek Morris at morrisdw@tcd.ie or Dr Elaine Kenny at elaine.kenny@tcd.ie
News in Brief
MMI Clinician Scientist Fellowship Programme External Review Recommendations
Dr Diana Dunstan (formerly Director of Research & Training at the Medical Research Council, and now working part-time for the UK Research Councils) and Professor John Iredale (Professor of Medicine at the MRC Centre for Inflammation Research, University of Edinburgh and Director of a Wellcome Trust funded Clinician Scientist Training Programme) undertook an… More »
Molecular Medicine Ireland publishes its first Annual Report
Molecular Medicine Ireland's first Annual Report is now available. This report provides a comprehensive summary of MMI's activities for the year 2008 including those relating to Irish Clinical Research Infrastructure Network (ICRIN) and the Dublin Centre for Clinical Research (DCCR) both of which form part of MMI's organisational structure. Highlights from the year… More »
The Translational Health Research Conference, College of Medicine and Health, University College Cork
Molecular Medicine Ireland attended the Translational Health Research Conference organised by the College of Medicine and Health at University College Cork, in association with Pfizer and the Cork Cancer Research Centre in Brookfield Health & Sciences Complex on 24 June 2009. The conference was well attended with over 180 registrants and up to 90 posters.… More »
ECRIN Newsletter August 2009
Issue 5 of the European Clinical Research Infrastructure (ECRIN) newletter is now available.
With articles on: The New ECRIN Logo; Summary of the ECRIN Annual Meeting held on 19th and 20th May in Milan, Italy; International Clinical Trials' Day 2009; ECRIN Scientific Board and approval of Multinational Clinical Trials; Upcoming ECRIN Education and Training… More »
Certificate in Nursing (Clinical Research) course - Stand-alone modules
FACULTY OF NURSING AND MIDWIFERY ROYAL COLLEGE OF SURGEONS IN IRELAND
Education Modules - Clinical Research
The Royal College of Surgeons in Ireland, working with the Dublin Centre for Clinical Research (DCCR) and Molecular Medicine Ireland, and supported by the Health Research Board (HRB) and the Wellcome Trust, are… More »
Upcoming Events
- Institute of Molecular Medicine (IMM) - 12th Annual Meeting
13 Nov 2009 to 14 Nov 2009 - British Medical Ultrasound Society: Pre-clinical ultrasound study day
20 Nov 2009 - IPPOSI National Strategic Forum for Clinical Research
27 Nov 2009 - MMI Course: MOLECULES TO MEDICINES - HOW BIOPHARMA DELIVERS
5 Nov 2009 - MMI/Wyeth Workshop - MOLECULES TO MEDICINES - How Biopharma Delivers
6 Nov 2009 - MMI Course: TECHNIQUES & STRATEGIES IN MOLECULAR MEDICINE
8 Dec 2009 to 9 Dec 2009 - Irish Association for Cancer Research Annual Meeting 3-5 March 2010
3 Mar 2010 to 5 Mar 2010