Following the fourth running of the MMI Drug Design & Delivery course, which took place on 12-13 October 2009 in RCSI, a small group of attendees will visit the TCD 3D visualisation facility on Wednesday 10 February 2009.

The visit, led by Dr Amir Khan (School of Biochemistry and Immunology, TCD), will include a demonstration of Estrogen Receptor bound to antagonists. This will give participants an excellent opportunity to see at first hand a state-of-the-art technology that enables researchers to view the interactions between receptors and candidate drugs.

Should you wish to read a report on the MMI Drug Design & Delivery course, please click on the following link:
http://www.molecularmedicineireland.ie/show/item/1/1344

Please find also further information on the Institute for Information Technology and Advanced Computation (IITAC) Visualisation Facilities at TCD via the following link
http://www.iitac.tchpc.tcd.ie/facilities/vis/  
 

Alternative formation of Helix-12 in Estrogen Receptor α due to bound 4-hydroxytamoxifen (antagonist) shown in orange and estradiol (agonist) shown in green. Key ligand-interacting amino acids within the binding pocket are displayed. (image courtesy of Dr Andrew Knox, Molecular Design Group, School of Biochemistry and Immunology, Trinity College Dublin)